administration of 2 ng/kg Escherichia coli endotoxin). Subsequently, all subjects underwent experimental endotoxemia (i.v. Subjects in the intervention group were trained for 10 d in meditation (third eye meditation), breathing techniques (i.a., cyclic hyperventilation followed by breath retention), and exposure to cold (i.a., immersions in ice cold water). Healthy volunteers were randomized to either the intervention ( n = 12) or control group ( n = 12). Herein, we evaluated the effects of a training program on the autonomic nervous system and innate immune response. However, both the autonomic nervous system and innate immune system are regarded as systems that cannot be voluntarily influenced. Acute activation of the sympathetic nervous system attenuates the innate immune response. Excessive or persistent proinflammatory cytokine production plays a central role in autoimmune diseases.
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